Electrospinning is a technique used to produce micro to nano-sized polymer fibers. This method is based on electrostatic forces; the application of electric field on the polymer solution leads to the projection of a jet and the creation of polymeric fiber. Many polymer solutions have been electrospun for different biomedical applications such as drug delivery applications. Thanks to its large surface area, the fiber structure can retain the biological fluid. In this study, a blend of Poly (N-vinylcaprolactam) (PNVCL), a thermoresponsive, biocompatible and hydrophilic polymer and polycaprolactone (PCL), a biodegradable, biocompatible and hydrophobic polymer was electrospun to create thermosensitive, biocompatible and biodegradable nanofibers. The electrospinning of PNVCL/PCL blend polymer solution was optimized to obtain continuous and smooth nanofibers; the morphology of PNVCL/PCL nanofibers was evaluated by Scanning Electron Microscopy (SEM). In addition to the process parameters, the solution concentration and the type of solvent were also optimized. Different morphologies of PNVCL/PCL fibers were obtained according to the solvent used. The biodegradation of the PCL particles created pores in the fiber which should facilitate drugs release. The particle size of PCL in PNVCL/PCL blend solution was evaluated by Dynamic Light Scattering(DLS). Keywords: Electrospinning, PNVCL, PCL, Nanofibers.